Based on the neuroprotective effects of SIRT1 on PD, many in vitro and in vivo experiments have demonstrated that some SIRT1 activators, notably resveratrol (RV), have potential neuroprotective effects against DA neuronal damage caused by various neurotoxins (20), but the specific molecular mechanism underlying its action requires further elucidation. Here, SIRT1 is linked to Parkinson disease.