CD274 and neoplasm: Once uncontrolled angiogenesis is ceased, the abnormal blood vessels in TME tend to be normalized to cope with sufficient oxygen supply, increased migration of antitumour immune cells, and enhanced penetration of antitumour agents into the tumor which contributed to the suppression thereof; however, it was found that molecular targeted therapy boosted upregulation of programmed death ligand-1 (PD-L1) in tumor tissues (Liu et al., 2015).