Regardless of the upregulation of PD-L1 attributed to REG, the immunosuppressive TME of CT26-Luc tumor was distinctly relieved of the effects of BMS202, characterized by the increased infiltration of CD8+ T cell in CT26-Luc tumor and enhanced secretion of antitumour cytokines (IFN-γ and TNF-α). This evidence concerns the gene CD274 and neoplasm.