Recent studies have noted the close correlation between the Piezo1 channel and some cancers, including gastric cancer, oral squamous cell carcinoma, prostate cancer, colon cancer, synovial sarcoma, and osteosarcoma (Jiang et al., 2017; Suzuki et al., 2018; Zhang et al., 2018; Han et al., 2019; Sun et al., 2020; Hasegawa et al., 2021; Wang et al., 2021). Here, PIEZO1 is linked to malignant colon neoplasm.