Mutations in human PIEZO1 and PIEZO2 can lead to a variety of hereditary diseases, including Piezo1-based dehydrated hereditary stomatocytosis (DHS) (Zarychanski et al., 2012) and generalized lymphatic dysplasia (Lukacs et al., 2015), and Piezo2-based distal arthrogryposis syndrome (Coste et al., 2013; McMillin et al., 2014), Gordon syndrome and Marden-Walker syndrome (McMillin et al., 2014). The gene discussed is PIEZO2; the disease is Marden-Walker syndrome.