Recently, it has been reported that luteolin can increase the degradation of YAP protein, thereby inhibiting epithelial mesenchymal transition and breast cancer cell migration (Cao et al., 2020), of which are implicated that luteolin may ameliorates pulmonary arterial hypertension via suppressing Hippo-YAP/PI3K/AKT signaling pathway. Here, YAP1 is linked to pulmonary arterial hypertension.