In addition, the level of serum hyperuricemia and blood urea nitrogen (BUN), as well as the expression of GLUT9 were decreased in chronic hyperuricemia mice induced by potassium oxonate after hirudin administration, which manifested that hirudin could exert obvious anti-hyperuricemia and anti-gout effects by regulating the expression of GLUT9 and protecting kidney (Liu et al., 2018). This evidence concerns the gene SLC2A9 and hyperuricemia.