In addition, the tumor resected from the HFD group expressed higher levels of CAV-1, LOX-1, CD133, Bmi-1, SOX-2, p-GSK-3β (S9)/GSK-3β and β-catenin than the tumor from the control group, while celastrol down-regulated the levels of these proteins (Figure 2J). The gene discussed is GSK3B; the disease is neoplasm.