However, unfortunately, a VAP-1 inhibitor BI 1467335 was recently discontinued for NASH indications due to its interaction with other drugs, although the results of the latest clinical studies (phase IIa, NCT03166735) did not indicate a direct failure of BI 1467335 in terms of efficacy and tolerance (Boehringer ingelheim, 2019). Here, AOC3 is linked to metabolic dysfunction-associated steatohepatitis.