NOS3 and metabolic dysfunction-associated steatotic liver disease: The dysfunction mechanism may be related to a decreased phosphorylation of Akt-dependent endothelial nitric oxide synthase (eNOS) and NO synthase activity, which reduces liver eNOS activity and NO content, respectively, and the consequence was occurred earlier than general liver inflammation in the rodent NAFLD model (Tateya et al., 2011; Pasarin et al., 2012; Gonzalez-Paredes et al., 2016; Bravo et al., 2019).