TIE1 and Hepatic fibrosis: Besides, LECT2, a functional ligand of endothelial cell-specific receptor Tie1, was recently found to promote liver fibrosis by inhibiting portal angiogenesis and promoting capillarization of liver sinusoids in various liver fibrosis models, providing a novel possible target for LSECs-mediated liver fibrosis (Xu et al., 2019).