It is worth noting that the therapeutic effect of L1-10, at least in part, is mediated by LSECs as evidenced by the downregulation of VCAM-1, ICAM-1, and CCL2 expression in liver endothelial cells isolated from the liver of NASH mouse (Lefere et al., 2019). This evidence concerns the gene VCAM1 and metabolic dysfunction-associated steatohepatitis.