CCL2 and metabolic dysfunction-associated steatohepatitis: In addition to this pro-inflammatory phenotype, LSECs produce pro-inflammatory mediators, including IL-1, IL-6, TNF-α, and CCL2, to promote activation of inflammatory cells and the recruitment, adhesion, and migration of BMMs and neutrophils in NASH (Miyachi et al., 2017; Roh and Seki, 2018; Hammoutene and Rautou, 2019).