There are many promising candidates in the drug development pipeline, and some have shown very useful for improving NASH by controlling inflammation in clinical trials (Table 2), such as dual CCR2/5 inhibitor, apoptosis signal-regulating kinase 1 (ASK1) inhibitor, and caspase inhibitor (Romero et al., 2020). This evidence concerns the gene MAP3K5 and metabolic dysfunction-associated steatohepatitis.