Further study demonstrated the anti-inflammatory ability produced by LSECs under FFA induction depends on the MAPK signaling pathway, which is important for the survival of LSECs in the case of lipid induction, and it also may be involved with signal transducer and activator of transcription 3 (STAT3) for its expression in LSECs alleviated mice liver inflammation induced by alcohol (Miller et al., 2010; Hang et al., 2012; McMahan et al., 2016). Here, STAT3 is linked to Hepatitis.