However, in another double-blind, placebo, randomized study, 10 mg of melatonin to 60 PD patients for 12°weeks significantly normalized Unified Parkinson’s disease Rating Scale part I score, PSQI, Beck Depression and Anxiety Inventories, and plasma levels of C-reactive protein, total antioxidant capacity, glutathione, LDL-cholesterol, glucose and insulin (Daneshvar Kakhaki et al., 2020). Here, INS is linked to Parkinson disease.