The above studies proved that high levels of FGF19 contribute to the development of HCC, function as an independent prognostic factor for survival, and may predict early recurrence of HCC after curative hepatectomy (Miura et al., 2012; Li et al., 2016b; Alvarez-Sola et al., 2017; Gao et al., 2017; Cui et al., 2018; Raja et al., 2019). This evidence concerns the gene FGF19 and hepatocellular carcinoma.