FGFR4 and hepatocellular carcinoma: FGFR4 selective reversible inhibitors, such as H3B-6527, roblitinib (FGF401), ABSK-011 and ICP-105, bind to the FGFR4 kinase domain in a reversible covalent manner and inhibit the progression of HCC; Whereas, fisogatinib (BLU-554) and BLU-9931 bind to FGFR4 in an irreversible manner.