FGFR2 and intrahepatic cholangiocarcinoma: FGFR1-3 gene mutations can be detected in 11% of intrahepatic cholangiocarcinoma (ICC) (Javle et al., 2016), FGFR2 gene fusion was detected in 11–45% of cholangiocarcinoma (CCA), and the common fusion forms mainly include FGFR2-ZMYM4, FGFR2-BICC1 fusion, etc (Saha et al., 2016).