FGF19 positively regulates the expression of the EGFR ligand amphiregulin and connective tissue growth factor (CTGF) to regulate the growth and survival of HCC cells (Castillo et al., 2006; Castillo et al., 2009; Urtasun et al., 2011; Latasa et al., 2012; Uriarte et al., 2015). The gene discussed is CCN2; the disease is hepatocellular carcinoma.