As shown in Figure 1A, the transcription levels of FGF1, 2, 7, 11–13, 17–19, and 21–22 and FGFR1–4 in hepatocellular tumor tissues are higher than those in normal tissues (Figure 1A); In addition, gene mutations, fusions, and copy number amplification of FGFs/FGFRs are closely related to the occurrence of HCC. This evidence concerns the gene FGF1 and hepatocellular carcinoma.