Consistent with the high expression levels of FGFR3 and FGFR4 in the liver, the overexpression of FGFR3 and/or FGFR4 was detected in the majority of HCC cases compared with the relatively rare upregulation of FGFR1 and/or FGFR2 (Cappellen et al., 1999; Paur et al., 2015). This evidence concerns the gene FGFR4 and hepatocellular carcinoma.