Consistently, FGF18 expression and secretion are upregulated in a high-RPS15 A-expression HCC tumor microenvironment; FGF18 interacts with FGFR3 and contributes to angiogenesis by inducing the Wnt/β-catenin signaling pathway in endothelial cells (Guo et al., 2018). Here, FGFR3 is linked to hepatocellular carcinoma.