Pronounced overexpression of FGF18 accelerates tumorigenesis via mediating cell proliferation, invasion, and angiogenesis, which is correlated with poor overall survival in patients and has been addressed in multiple types of cancers, such as HCC, colorectal carcinomas, ovarian cancers, and gastric cancer (Gauglhofer et al., 2011; Koneczny et al., 2015; El-Gendi et al., 2016; Flannery et al., 2016; Zhang et al., 2019a; Zhang et al., 2019b; Jomrich et al., 2019; Kulbe et al., 2019). Here, FGF18 is linked to hepatocellular carcinoma.