NFKB1 and diabetes mellitus: Advanced glycation end products (AGEs) and the consequential enhanced oxidative stress and low-level inflammation are also among the underlying causes of vascular complications of diabetes, and HSP70 is able to inhibit these inflammatory processes by sequestering NFkB, thereby reducing NFkB-induced iNOS expression and thus decreasing formation of reactive oxygen species (ROS) and peroxynitrites (Bellini et al., 2017).