EGFR and non-small cell lung carcinoma: High levels of FBXW7 and low levels of c-MYC were observed in gefitinib-resistant cells with EGFR exon 19 deletion, suggesting that FBXW7 plays a pivotal role in the maintenance of gefitinib resistance in EGFR mutation-positive NSCLC (Hidayat et al., 2019).