By reviewing the adverse events reported in clinical trials, it was found a dose-response relationship between osteonecrosis and NGF antibodies, with the dose of Tanezumab ranging from 2.5 to 10 mg and the dose of Fasinumab ranging from 3 to 9 mg (Hochberg, 2015; Lane and Corr, 2017; Dakin et al., 2019). Here, NGF is linked to osteonecrosis.