IRAK1 and gout: Our previous study (Zhang et al., 2018) used miR-146a knockout mice to test miR-146a function in a MSU-induced gouty arthritis model, and the results indicated that the lack of miR-146a enhances the inflammation level of gouty arthritis via upregulation of TRAK6, IRAK-1, and the NALP3 inflammasome function.