The targeted binding of miR-223 to NLRP3 mRNA increases, which inhibits the activity of NLRP3 inflammasomes and reduces the release of IL-1β, thereby reducing acute inflammation, which also better explains the phenomenon that gout patients can spontaneously relieve within 7–14 days after an acute gout flare (Dalbeth et al., 2016). Here, IL1B is linked to gout.