NLRP3 and gout: NLRP3 inflammasome (NLRP3, apoptosis-associated speck-like protein (ASC), and caspase-1) signaling is involved in the pathogenesis of interleukin (IL)-1β-mediated gouty arthritis (Martinon et al., 2006; So and Martinon, 2017; Renaudin et al., 2020).