The occurrence of MSU-mediated gout inflammation is a complex process, including the phagocytosis of autoimmune cells, the negative regulation of inflammatory mediators such as NLRP3 inflammasomes, Toll-like receptors and IL-1β, and the formation of aggregated neutrophil extracellular traps, etc (Qing et al., 2014; Dalbeth et al., 2016). The gene discussed is NLRP3; the disease is gout.