MTOR and cardiac hypertrophy: A study documented that in a rat cardiac hypertrophy model, Pue activated autophagy to alleviate cardiomyocyte hypertrophy and apoptosis by activating the phosphorylation of 5′AMP-activated protein kinase (AMPK) and inhibiting mTOR signaling, and this protective effect was blocked by the autophagy inhibitor, 3-methyladenine (Liu et al., 2015).