Since activation of the mTOR signaling pathway is ubiquitous in cancers, therapeutic inhibition of mTOR using analogs of Rapamycin (‘Rapalogs’) has been an attractive strategy for systemic management of cancer, albeit with modest benefits (Kwitkowski et al., 2010; Yao et al., 2011; Buti et al., 2016; Hua et al., 2019). This evidence concerns the gene MTOR and cancer.