Prior attempts to identify potentially synergistic and safe anticancer drug combinations (Wang and Sorger, 2017; Sidorov et al., 2019; Zagidullin et al., 2019) as well as to predict drug efficacy via in vitro CRP of cell lines or primary tumor cellsy (Hurvitz et al., 2015; Mercatali et al., 2016; Kuo et al., 2019) reflect a consensus in favor of personalized combination regimens based on molecular and functional evidence. This evidence concerns the gene CRP and neoplasm.