COL4A4 and Wilson disease: In particular, 11 collagens (COL1A1, COL1A2, COL4A3, COL4A4, COL4A5, COL4A6, COL6A1, COL6A2, COL6A3, COL6A5, and COL9A3), 5 integrins (ITGA11, ITGA3, ITGA8, ITGB6, and ITGB7), 6 laminins (LAMA2, LAMA4, LAMA5, LAMB1, LAMB2, and LAMC2), and 3 thrombospondins (THBS1, THBS2, and THBS3) were upregulated in WD, and GDFMD could effectively reverse their abnormal expression levels.