We found that hundreds of immune factors, including 133 cytokines and cytokine receptors, 13 interleukins and interleukin receptors, 8 TNF family members and receptors, 10 TGF-β family members and receptors, and 34 chemokines and receptors, are dysregulated in WD, and that GDFMD could revert these dysregulations. The gene discussed is TNF; the disease is Wilson disease.