CD8A and non-small cell lung carcinoma: Furthermore, Wang X. et al. (2018) showed that in patients with NSCLC, lentinan significantly increased the number of CD3+CD56+NKT cells, up-regulated CD4+ and CD8+ cell subsets, increased the levels of IFN-γ, TNF-α, and IL-12, and decreased the levels of IL-10 and TGF-β1 in patients with NSCLC.