The deiodinase enzyme levels may be upregulated or downregulated in the tumor cells depending on the status of the critical intracellular signaling pathways, such as Wingless-related integration (Wnt), mitogen-activated protein kinase (MAPK), and Sonic-hedgehog (Shh) thus reducing its catalytic efficiency (Goemann et al., 2018). This evidence concerns the gene WNK2 and neoplasm.