Immunohistochemical stains for LCIS and its variants have exhibited a complete or partial loss of cell-cell adhesion protein epithelial-Cadherin (E-cadherin) expression and the presence of p120 cytoplasmic catenin which is considered as the positive marker for LCIS (Chen et al., 2009; Wen and Brogi, 2018). Here, CDH1 is linked to lobular breast carcinoma in situ.