EGF and neoplasm: Other mechanisms that play a role are: 1) intravasation of macrophages via the epidermal growth factor or colony-stimulating factor 1, 2) signaling pathway of paracrine, 3) the microenvironment of the tumor, 4) the vessel wall elements surrounding the intravasation of tumor cell clusters, 5) cooperative intravasation and 6) intravasation associated with the vasculogenic mimicry (Marciel and Hoffmann, 2017; Zavyalova et al., 2019).