Collagen VI which is upregulated in the extracellular matrix of obese tumor-bearing mice causes adhesion, migration, and invasion of human breast cancer cell lines through adhesion receptor, neuron-glial antigen 2 (NG2), and tyrosine kinase epidermal growth factor receptor (EGFR) receptor crosstalk, and Mitogen-activated protein kinases (MAPK) signaling activation (Wishart et al., 2020). The gene discussed is WNK2; the disease is neoplasm.