MAPT and Dravet syndrome: As in DS, many of these phenotypes appear at prenatal stages, and during adulthood, the TS mouse also exhibits increased levels of APP, Aβ peptides, tau hyperphosphorylation, and neurodegeneration (Lockrow et al., 2009; Shichiri et al., 2011; Corrales et al., 2013, 2014; García-Cerro et al., 2017).