Tachibana et al. (2016) found that several key synaptic proteins that regulate plasticity (i.e., PSD95, Glutamate Receptor 1 (GluR1), and N-methyl-d-aspartate Receptor NR1 subunit (NR1)), which are reduced in aged animals, are restored in the brains of wild-type mice after bexarotene treatment. In addition, Muñoz-Cabrera et al. (2020) reported a recovery of basal synaptic transmission and synaptic plasticity in 3xTg-AD mice after bexarotene administration. Here, GRIA1 is linked to Alzheimer disease.