U87MG cells treatment with AS1411-functionalized poly (l-γ-glutamyl-glutamine)-paclitaxel (PGG-PTX) nanoconjugates showed a 3.5 fold greater cell growth inhibition than that of unconjugated PGG-PTX; this was due to AS1411-nucleolin mediated endocytosis of PGG-PTX, and, indeed, the AS1411 conjugation enhanced the accumulation of AS1411-PGG-PTX nanoconjugates in different organs of glioblastoma-bearing nude mice, after 24 h intravenous injection. This evidence concerns the gene NUCLEOLIN and glioblastoma.