In accordance with the metal hypothesis of AD, Aβ deposition, and tau hyperphosphorylation are aggravated by metal ions, thus promoting the development of AD (Liu et al., 2011; Zhang et al., 2019; Ejaz et al., 2020; Singh et al., 2020; Spotorno et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.