Several studies have revealed that mTOR signaling may be correlated to neurodegenerative diseases (Garelick and Kennedy, 2011; Heras-Sandoval et al., 2014), including Parkinson disease, Huntington’s disease, Alzheimer’s disease (Bockaert and Marin, 2015). The gene discussed is MTOR; the disease is early-onset autosomal dominant Alzheimer disease.