NFKB1 and Alzheimer disease: At the molecular level, NF-κB plays a role in AD by regulating various downstream effectors, including the molecules involved in signaling pathways, such as the PI3K/AKT, MAPK, and AGE/RAGE/GSK-3, and newly discovered noncoding RNAs (ncRNAs), which mediate neuronal toxicity or protection (Shi et al., 2016).