Our findings were also corroborated by another recent study demonstrating that withdrawal from experimenter-delivered nicotine exposure in mice upregulates TNFα and IL-1β mRNA within the NAc and increases anxiety-like behavior, both of which are prevented by pharmacological depletion of microglia with a colony-stimulating factor 1 receptor inhibitor (Adeluyi et al., 2019). The gene discussed is TNF; the disease is Anxiety.