These data suggest that CTLA4, SQSTM1, CDKN1B, GATA3, FASN, PARK7, BAX, RICTOR, NAPSA, PDK1, MACC1, PEA15, BCL2, GSK3A, GSK3B, TSC2, STAT3, AKT1, AKT2, AKT3, TSC1, AXL, PDCD1, MAPK1, MSH2, RPS6KB1, BID, MTOR, EIF4EBP1, BAP1, ETS1, KEAP1, XRCC5, ERBB3, TP63, CASP3, PXN, FOXO3 and NOTCH (P value < 0.05) were primarily correlated with genomic alterations of Kindlins in NSCLC. The gene discussed is PDK1; the disease is non-small cell lung carcinoma.