PTEN and hepatocellular carcinoma: For instance, miR-616 enhances HCC cell proliferation, migration, and invasion by inhibiting phosphatase and tensin homolog (PTEN) expression and activating the phosphatidylinositol-3 kinase (PI3K)/AKT pathway; miR-616 high expression is positively linked to lymph node metastasis and Tumor-Node-Metastasis (TNM) staging [9].