On univariate analysis, worse ECOG‐PS (≥2), the presence of liver metastasis, the presence of bone metastasis, lower Hb, high serum lactate dehydrogenase (LDH) levels (≥ULN), and high serum CRP levels were extracted as factors predictive of a shorter OS as shown in Table 3. This evidence concerns the gene CRP and bone metastasis.