The study by Gang G. Wang et al. found that the main transformation characteristic of NUP98–NSD1 is that it does not allow cell differentiation, thereby promoting self‐renewal of progenitor cells, and in experiments found that NUP98–NSD1 can enhance self‐renewal by activating Hox‐A gene and Meis1 transcription and to prevent differentiation, the potent leukemia oncogenes HoxA9 and Meis1 are co‐expressed in NUP98–NSD1 immortalized progenitor cells. This evidence concerns the gene NSD1 and leukemia.