Therefore, to explore the effects of endothelial IGF‐1R on metabolic responses to obesity and the microbiome, we fed mice with endothelial cell overexpression of human IGF‐1R (hIGFREO) (Imrie et al,2012) an obesogenic high‐fat high‐calorie diet. The gene discussed is IGF1R; the disease is obesity due to melanocortin 4 receptor deficiency.