Through the network construction of ceRNA crosstalk and pathway enrichment of related mRNAs, PIK3R2 was identified as core genes to involve in pathways of cell communication, signaling transduction, and cancers through regulations of BVES‐AS1/miR135b, BLACAT1/miR‐30, SAMD12‐AS1/miR‐30, and MIR205HG/miR‐30 axes. This evidence concerns the gene PIK3R2 and cancer.