ROC curve analysis also revealed a lack of or minimal predictive ability of the genetic risk markers and Aβ misfolding to predict VD (AUC, 95% CI: Aβ PRS: 0.52, 0.45–0.61; AD PRS: 0.56, 0.48–0.64; APOE: 0.50, 0.42–0.57; Aβ misfolding: 0.54, 0.46–0.63). Here, APOE is linked to Alzheimer disease.