APOE and Alzheimer disease: Aβ misfolding exhibited superior AD diagnosis prediction ability compared to the genetic markers (AUC, 95% CI: Aβ PRS: 0.55, 0.46–0.63 AD PRS: 0.59, 0.51–0.68; APOE ε4: 0.63, 0.55–0.70; Aβ misfolding: 0.84, 0.78–0.90) (Fig. 2).