The Alzheimer’s disease polygenic risk score and APOE ε4 presence were associated to Aβ misfolding (odds ratio, 95% confidence interval: per standard deviation increase of score: 1.25, 1.03–1.51; APOE ε4 presence: 1.61, 1.04–2.49). The gene discussed is APOE; the disease is Alzheimer disease.