HIF1A and pancreatic neoplasm: In line with published data, we could confirm an activation of HIF1α in pancreatic tumors, as shown by the nuclear accumulation of the HIF1α reporter protein mcherry fused with the nuclear localization signal (nls; Supplementary Fig. 5a, lower panel), and an enhancement of HIF1α protein levels in cancer samples with respect to wild-type pancreas (Fig. 5a and Supplementary Fig. 5d).