Meanwhile, nuclear β-catenin protein, the downstream target of lnc408/CBY1 axis, was significantly increased in the tumor derived from injected BCSC (BCSC/shCtrl) compared to the tumor from injected non-BCSCs (non-BCSC/Vec), and it was reduced in tumor derived from lnc408-silenced BCSCs (Fig. 7C). The gene discussed is TOMM22-DT; the disease is neoplasm.