Compared with the fish embryos of the control group (exposed to 0.1% DMSO, v/v), which exhibit normal development, intracranial hemorrhage was observed in the group treated with ADAMTS-5 inhibitor (ATS5-in 0.5 μg/mL) from 36 hpf to 72 hpf (Figure 7A). Here, ADAMTS5 is linked to intracranial hemorrhage.