TNF and aneurysm: After aneurysm induction, rADAMTS-5-administered mice showed a significant difference in the expression of multiple inflammatory mediators (tumor necrosis factor-α [TNF-α], matrix metalloproteinase [MMP]-2, interferon-γ [IFN-γ], nuclear factor kappa B [NF-κB]-p65, and nuclear factor kappa B [NF-κB]-p50) when compared with control IA mice (Figure 4B).