Since reverse mode NCX activity is elicited in cardiomyocytes under pathophysiological conditions, such as ischemia/reperfusion injury [31] and heart failure [32], the activity of reverse mode NCX may be suppressed in neutrophils, and, thus, reverse mode NCX may not be involved in EIPA- and MIA-mediated NETotic cell death. This evidence concerns the gene TLX2 and heart failure.