IGHE and anaphylaxis: In fact, within specific geographic areas anaphylaxis due to alpha-gal IgE seroconversion is more common than all other forms of dietary anaphylaxis combined.4,7 Although a majority of patients knowingly or unknowingly avoid these products, others continue to experience symptoms and eventually diagnosed with alpha-gal syndrome (AGS), a diagnosis based on clinical symptoms and alpha-gal IgE >0.1 IU/mL.