One recent GWAS encompassing almost 20,000 individuals with T1DM [13] identified 16 risk loci including the missense mutation rs55703767 in COL4A3. Additional GWAS have identified nucleotide variants in rs7583877 in AFF3 [14], rs1888747 and rs10868025 in FRMD3, [15] and rs4972593 in CDCA7-SP3 [16]. This evidence concerns the gene AFF3 and type 1 diabetes mellitus.