The average cumulative risk of LS-RC in MLH1 and MSH2 mutation carriers was 9.7 %, 38.9 %, 69.5 %, 92.4 %, CRC was 9.7 %, 36.4 %, 66.7 %, 81.3 %, and gastric cancer was 0, 1.4 %, 6.1 %, 29.6 %, at age 30, 40, 50, 60 years old, respectively [20]. Here, MSH2 is linked to colorectal carcinoma.