In Pakistan, pathogenic/likely pathogenic MLH1/MSH2 variants account for a large proportion of HNPCC/suspected HNPCC colorectal cancer, mainly including three recurrent variants (MLH1 c.1358dup and c.2041G > A; MSH2 c.943-1G > C) [17]. The gene discussed is MSH2; the disease is hereditary nonpolyposis colon cancer.