TLR3 and neoplasm: In addition, release of TNF-α and IFN-γ, well-established potent anti-tumor factors, was also significantly induced after 24 h of stimulation with 10 MOI reovirus or Poly(I:C), but decreased after treatment with TLR3/dsRNA complex inhibitor (Fig. 5e).Together, these results indicate that TLR3 serves as the primary receptor for modulating the activation and function of NK cells by reovirus.