EGFR and colorectal cancer: Moreover, the ability of reovirus to enhance NK cytotoxicity makes it an ideal candidate for combination therapeutic strategies, such as with cetuximab.To examine whether reovirus activation of NK cells also enhances ADCC against EGFR-expressing CRC cells, we used ex vivo expanded NK cells activated with 10 MOI reovirus for 12 h to perform ADCC assays on colorectal cancer cells also treated with cetuximab.