In addition, release of TNF-α and IFN-γ, well-established potent anti-tumor factors, was also significantly induced after 24 h of stimulation with 10 MOI reovirus or Poly(I:C), but decreased after treatment with TLR3/dsRNA complex inhibitor (Fig. 5e).Together, these results indicate that TLR3 serves as the primary receptor for modulating the activation and function of NK cells by reovirus. Here, TNF is linked to neoplasm.