Several biomarkers, including CRP, ESR, IL-18, S100A8/A9 and S100A12 were elevated in systemic JIA when compared to other JIA categories, whereas inter-category differences in CXCL10, G-CSF, IL-17A and MMP-3 levels were not consistent (Fig. 2b). Here, MMP3 is linked to juvenile idiopathic arthritis.