On the other hand, studies have found that Prospero Homeobox 1 (PROX1) can inhibit the expression of HIF-1α: CCl4-induced liver fibrosis mice, curcumin inhibits LSECs angiogenesis by regulating the Glis-PROX1-HIF-1α signaling pathway, thus slowing down the development of liver fibrosis [37]. This evidence concerns the gene HIF1A and Hepatic fibrosis.