At the same time, lncRNA H19 is a negative regulator of miRNA-148b-3p and can participate in the hypoxic stress of LSEC through positive regulation of NOX4 and negative regulation of eNOS/NO signaling pathways [73], while LSEC activated by hypoxia will participate in the occurrence and development of liver fibrosis. This evidence concerns the gene H19 and Hepatic fibrosis.