Via tightly hypoxia-regulated induction of the transcriptional activator hypoxia inducible factor (HIF), a cascade of target genes and cell surface receptors encoded by most genes which expressed in vascular endothelial cells and increase the sensitivity of endothelial cells to angiogenic factors, as well as accelerate the process of liver fibrosis [31]. This evidence concerns the gene CD177 and Hepatic fibrosis.