Tumor cells release various soluble chemokines and cytokines into the extracellular environment in interaction with other cells which can recruit MSCs and immune cells toward tumor sites [56] based on reports of previous studies, oncolytic reovirus can affect iron homeostasis (iron/ROS metabolism) in infected MSCs and consequently, it can cause increasing the CXCR4 expression on MSCs surface and enhance their migration potency [60–62]. Here, CXCR4 is linked to neoplasm.