VEGFA and neoplasm: In conclusion, the results of this study revealed that MSCs loaded with reovirus (MSC-RV) and MSCs can suppress tumor progression by several probable mechanisms that involved (i) NF-κB pathway (ii) Interferon-Stimulated Gene (ISG) expression (iii) apoptotic bodies formation (iv) direct viral particle effect (active or dead particles (v) as a transport vehicle (vi) down-regulation of WNT signaling pathway [21] (vii) down-regulating the expression of vascular endothelial growth factor (VEGF) [78, 82] (viii) activation and recruitment of CTL and TCD4 + and immune cells toward the tumor site.