The results revealed that a high pre-treatment CAR was associated with older age (odds ratio [OR] 1.470, p = 0.007), male sex (OR 1.452, p = 0.001), location (colon vs. rectum, OR 1.724, p = 0.008), differentiation (poor vs. moderate/high, OR 1.611, p = 0.002), stage (III/IV vs. I/II, OR 2.255, p < 0.001), high CEA (OR 2.111, p = 0.042), tumor size (> 50 mm vs. < 50 mm, OR 3.687, p < 0.001), high NLR (OR 2.452, p = 0.002), and advanced mGPS (1 vs. 0, OR 21.405, p < 0.001). Here, CEACAM5 is linked to neoplasm.