LRRC4 and amyotrophic lateral sclerosis: In Fig. 4c, we are surprised finding that the KEGG pathway of up-regulated DEGs by LRRC4 decency is associated with amyotrophic lateral sclerosis, in which Rab7b was obvious upregulated gene and of special interest, and it was recently shown that Rab7b is involved in activation of NF-κB and enhances the production of IL-6 (He et al. 2011).