Our previous study revealed that in GBM cells, LRRC4 interacted with phosphoinositide-dependent protein kinase 1 (PDPK1) and HSP90, which lead to IKKβ phosphorylation and NF-κB activation, and IL-6, CCL2, and IFN-γ production. The gene discussed is NFKB1; the disease is glioblastoma.