The factors related to CNS involvement are reported as monocytic component predominant AML, systemic relapse of acute promyelocytic leukemia (APL), presence of inversion 16, chromosome 11 anomalies, hyperleukocytosis, lactate dehydrogenase (LDH) elevation, and FLT3–internal tandem duplication (ITD) mutations [4–9]. Here, FLT3 is linked to acute promyelocytic leukemia.