TP53 and neoplasm: In a mechanistic study with different types of tumour cell lines, the silencing of Grx1 activated the p53 signalling pathway, causing the cell cycle to stop in G1 causing senescence [188], which supported the idea that antioxidant systems, including Grx1, get upregulated in tumour cells as survival mechanism to counteract the high amount of ROS due to the changes in metabolism.