In the study by Mollbrink and colleagues, with immunohistological analysis of liver paraffinized patient samples, it was observed that there was an increase in the expression of Trx1, Trx2, and Grx5 in tissue of patients with hepatocellular carcinoma (HCC) and colorectal carcinoma (CRC) in liver metastasis compared to the healthy surrounding tissue from the same patients. This evidence concerns the gene GLRX5 and hepatocellular carcinoma.