NFKB1 and cancer: Aberrant NF-κB activation and chemokine/cytokine expression are not only associated with pathogenesis of several inflammatory diseases, such as multiple sclerosis, rheumatoid arthritis, chronic obstructive pulmonary disease, and asthma (23, 24, 25, 26) but are also widely implicated in inflammation-induced neoplasia and cancer (27, 28, 29).