The HIES have historically been defined by the triad of elevated IgE, dermatitis, and recurrent skin and lung infections and include diseases caused by mutations of STAT3 [1, 2], TYK2 [6], PGM3 [7], ZNF341 [8], CARD11 [9], and IL6ST [10, 11]. The gene discussed is STAT3; the disease is dermatitis.