Ligands transducing through STAT3 include IL-6, IL-10, IL-11, IL-21, IL-22, and IL-23 [5]; aberrant transduction of these pathways coupled with STAT3′s ubiquitous expression explain the multisystem manifestations of this syndrome including dermatitis, pulmonary disease, vasculopathy, and skeletal and connective tissue abnormalities. The gene discussed is STAT3; the disease is vascular disorder.