Grimbacher et al.’s series [25] of 30 affected patients and 70 family members defined STAT3-HIES as a multi-system disorder by adding retention of primary dentition, scoliosis, and non-infectious vascular events such as cerebrovascular thromboembolic disease and aneurysms to the syndrome and identifying an autosomal dominant inheritance pattern, allowing distinction from a distinct consanguineous cohort subsequently found to have DOCK8 deficiency [26]. This evidence concerns the gene STAT3 and aneurysm.