ABPA, caused by hypersensitivity to Aspergillus and leading to further bronchiectasis and bronchospasm, is challenging to diagnose due to standardized criteria relying on raised IgE and eosinophilia that may be present in STAT3-HIES patients without Aspergillus isolation; diagnosis relies instead on classic imaging findings [55]. The gene discussed is IGHE; the disease is Increased total eosinophil count.