Venn analysis of the union of (i) profoundly downregulated M2 DEGs, (ii) hypermethylated genes (methylation FC >1.0), and (iii) ARF GTPase‐associated genes identified PSD4 as a key candidate repressed gene in alcohol‐related HCC (Figure 1H). Here, CDKN2A is linked to hepatocellular carcinoma.