Additionally, considering that PSD4 downregulation is unique to alcohol‐related HCC (Figure 1H,J) and ALD is associated with more pronounced canonical TNF‐α/NF‐κB signaling,17, 18 we hypothesized that enhanced TNF‐α/NF‐κB signaling may regulate PSD4 expression in HCC cells. The gene discussed is PSD4; the disease is hepatocellular carcinoma.