In addition to BRCA1 and BRCA2, at least seven other genes [ATM,13, 14, 15 CDH1,16, 17 CHEK2,18, 19 NF1,20, 21 PALB2,22, 23 PTEN,24, 25 and TP5326, 27 ] are associated with the risk of breast cancer (https://www.genecards.org/Search/Keyword?queryString=breast%20cancer), which has been used to provide information for breast cancer risk management. The gene discussed is CHEK2; the disease is breast carcinoma.